@article{Sivak_Grabovyj_Verovkina_Lyalkin_Majdanevych_Askolskyy_Klimanov_2017, title={Immune microenvironment in breast cancer}, url={https://liksprava.com/index.php/journal/article/view/19}, DOI={10.31640/LS-2017(1-2)12}, abstractNote={<p>Traditionally, breast cancer has not been considered as a typical immunogenic tumor type. Nevertheless, it is well known that breast cancer is a heterogeneous mixture of different molecular subtypes and infiltration of tumor tissue by immunocompetent cells is associated with response to chemotherapy and survival in a certain molecular subtypes of breast cancer. Analysis of works of various research groups suggests that, immune markers, such as the presence of CD8 + lymphocytes, T regulatory cells in the tumor, as well as the ratio of CD8/CD4T should be used to stratify risk groups with prognostically unfavorable types of breast cancer as well as use as a factor in predicting the effectiveness of anti-HER2 therapy and chemotherapy for triple negative and HER2-overexpressing breast cancer subtypes.</p&gt;}, number={1-2}, journal={Likars’ka sprava}, author={Sivak, L. A. and Grabovyj, A. N. and Verovkina, N. O. and Lyalkin, S. A. and Majdanevych, N. M. and Askolskyy, A. V. and Klimanov, M. Yu.}, year={2017}, month={Mar.}, pages={83-88} }