Иммунологическая диагностика поражений миокарда, вызванных энтеровирусной инфекцией

Yu. I. Zhdanyuk; Е. А. Gomozova; D. А. Lesnichenko; G. S. Taktashov

doi:10.31640/LS-2017(1-2)08

Yu. I. Zhdanyuk Donetsk National Medical University
Е. А. Gomozova Donetsk National Medical University
D. А. Lesnichenko Donetsk National Medical University
G. S. Taktashov Donetsk National Medical University

DOI: https://doi.org/10.31640/LS-2017(1-2)08

Keywords: enteroviruses Coxsackie and Echo, myocardium damage, immunological diagnostics, specific immunoglobulins M, A, G classes

Abstract

127 patients with myocardium damage induced by enteroviral infection (63 male and 64 female ones, aged 19–67) have been under medical observation and have been examined. Enteroviral infection diagnosis has been confirmed due to the detection of higher levels of specific antibodies (class M, A and G immunoglobulins – Ig) to Coxsackie and Echo enteroviruses with enzyme multiplied immunoassay. 15,7 % of patients have had accurate increment (Р < 0.05) only of IgM, 7,1 % – of IgA, 16,5 % – of IgG. Complex accurate increment (Р < 0.05) of IgM and IgG has been attributable for 19.7 % patients, IgA and IgG – for 5.5 % and IgA and IgM for 10.2 % patients. Immunoglobulin of all classes (A, M, and G) accurate increment (Р < 0.05) has been attributable for 25.2 % examined patients. Weak connection (Таu = 0.296, Р < 0.05) has been distinctive only between the levels of IgM and IgA, in a group of patients with the rise of all kinds of specific immunoglobulins. It has been stated that all specific immunoglobulins (Coxsackie and Echo cardiotropic virus immune bodies) are independent markers in diagnostics of enteroviral infection, provoking cardiac pathology development, so its determination is necessary for diacrisis verification.

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Immunological diagnostics of myocardium damage induced by enteroviral infection

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