Examination of vascular endothelial factor of growth in patients with alopecia areata

  • I. M. Serbina Kharkov Medical Academy of Postgraduate Education
Keywords: alopecia areata, pathogenesis, vascular endothelial factor ofgrowth, soluble receptor of vascular endothelial factor of growth

Abstract

The results of assessment of state of indexes of vascular endothelial factor of growth (VEGF) and its soluble receptor (sVEGFR1) in case of alopecia areata depending on activity of inflammatory process, degree of severity and length of illness, are presented. Imbalanceof angiogenic factors is presented by multidirectional changes of indexes. Increase of serum concentration of VEGF and decrease of sVEGFR1 is registered with the growth of activity of illness, during chronic stage the level of VEGF is veraciously falling in comparison to results of healthy individuals. Most significant violations are identified in patients with signs of activity and severe course of disease.

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References

1. Болотная Л. А., Сербина И. М., Сариан Е. И.Сосудистый эндотелиальный фактор роста и его патогенетическое значение при заболеваниях кожи // Дерматовенерология, косметология, сексопатология. – 2011. – № 1/4. – С. 88–94.

2. Гаджигороева А. Г., Коган Е. А., Потекаев Н. Н., Терещенко Г. П. Соотношение процессов апоптоза, пролиферации, неоангиогенеза и клеточной дифференцировки при иммунном воспалении в очагах гнёздной алопеции // Клин. дерматология и венерология. – 2010. – № 2. – С. 23–31.

3. Киселёва Е. П., Крылов А. В., Старикова Э. А., Кузнецова С. А.Фактор роста сосудистого эн-дотелия и иммунная система // Успехи соврем. биологии. – 2009. – Т. 129, № 4. – С. 1–12.

4. Кубышкин В. Ф., Мангилёва Т. А., Малый К. М.Сосудистый эндотелиальный фактор роста у больных артериальной гипертензией І степени // Серце і судини. – 2013. – № 1. – С. 32–37.

5. Gilhar A., Etzioni A., Paus R. AlopeciaAreata // N. Engl. J. Med. – 2012. – Vol. 366. – P. 1515–1525.

6. Maurer B., Distler A., Suliman Y. A.et al. Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis // Ann. Rheum. Dis. – 2013. – Vol. 10. – P. 11–36.

7. Olsen E., Hordinsky M. K., Price v.et al. Alopecia areata investigational assessment guidelinese. Part II // J. Am. Acad. Dermatol. – 2004. – Vol. 51. – Р. 440–447.

8. Simonetti O., Lucarini G., Bernardini M. L.et al. Expression of vascular endothelial growth factor, apoptosis inhibitors (survivinand p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study // Br. J. Dermatol.– 2004. – Vol. 150, N 5. – P. 940–948.

9. Tembhre M. K., Sharma V. K.T-helper andregulatory T-cell cytokines in the peripheral blood of patients with active alopecia areatа // Br. J. Dermatol.– 2013. – Vol. 169. – Р. 543–548.

10. Tosti A.Dermoscopy of hair and scalp disorders: pathological and clinical correlations. – Informa Healthcare, 2007. – 168 p.

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Published
2017-06-18
How to Cite
Serbina, I. M. (2017). Examination of vascular endothelial factor of growth in patients with alopecia areata. Likars’ka Sprava, (3-4), 98-103. https://doi.org/10.31640/LS-2017(3-4)18
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