The possibility of improving kidney function in patient with systolic dysfunction of left ventricle on the background of ischemic heart disease and hypertension

  • L. A. Kovalevskaya Odessa National Medical University
  • L. I. Zagorodnya Оdessa National Medical University
  • T. V. Voronina Оdessa National Medical University
  • V. S. Goidyk Оdessa National Medical University
  • V. I. Khrushch Оdessa National Medical University
  • O. A. Gerasymenko Оdessa National Medical University
Keywords: chronic heart failure, cardiorenal, renal functional reserve, treatment

Abstract

The aim of the study was to evaluate the clinical efficacy of pharmacological therapy of kidney function in patients with impaired left ventricular systolic function on the background of coronary heart disease and hypertension applying basic treatment with pentoxiphylline inclusion. There was shown that the use of pentoxiphylline in the complex therapy of chronic heart failure can increase renal reserve by 21.4 % compared with convention treatment. It is proved that the application of pentoxiphylline in the complex therapy in 43 (81.1 %) patients could reduce display of signs of congestive heart failure and increase the GFR in 38 (71.7 %) patients reverse the signs proteinuria. Due to the increasing normalization of GFR and ductal transport daily excretion of electrolytes (potassium, sodium and chlorine) has been normalized in 69.3 % of patients. Combined therapy with the use of methylxanthine derivatives improved the exercise tolerance (473,8 ± 6,1 m in the perfor- mance test of 6-minutes walking).

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Abstract views: 77
PDF Downloads: 89
Published
2017-06-18
How to Cite
Kovalevskaya, L. A., Zagorodnya, L. I., Voronina, T. V., Goidyk, V. S., Khrushch, V. I., & Gerasymenko, O. A. (2017). The possibility of improving kidney function in patient with systolic dysfunction of left ventricle on the background of ischemic heart disease and hypertension. Likars’ka Sprava, (3-4), 26-31. https://doi.org/10.31640/LS-2017(3-4)05
Section
Original investigations