Современные представления о синдроме эутиреоиднои патологии в клинической практике

N. O. Abramova; N. V. Pashkovska

doi:10.31640/LS-2017(1-2)04

N. O. Abramova Higher State Educational Establishment of Ukraine «Bukovinian State Medical University»
N. V. Pashkovska Higher State Educational Establishment of Ukraine «Bukovinian State Medical University»

DOI: https://doi.org/10.31640/LS-2017(1-2)04

Keywords: nonthyroidal illness syndrome, low T3 syndrome, violation of thyroid hormones metabolism

Abstract

Any acute and chronic diseases that involve the whole organism into pathological process, can cause violation of thyroid hormones metabolism against a background of absence of concomitant diseases of thyroid gland, pituitary gland or hypothalamus. Such violations are called "nonthyroidal illness syndrome" (NTIS) or "low T3 syndrome" and occur in 70 % of hospitalized patients. In this review we described etiology, pathogenesis and partly ways of correction of NTIS.

Downloads

Download data is not yet available.

References

Демидова Т. Ю., Галлиев О. Р. Роль гипофункции щитовидной железы в развитии метаболического синдрома // Терапевт. арх. – 2009. – № 4. – С. 69–73.

Логвиненко А. О. , Мітченко О. І., Романов В. Ю. та ін. Особливості ліпідного та вуглеводного обмінів у хворих з метаболічним синдромом та дисфункцією щитоподібної залози // Укр. кардіол. журн. – 2009. – № 4. – С. 56–61.

Asvold B. O. Association of serum TSH with high body mass differs between smokers and never-smokers // J. Clin. Endocrinol. Metab. – 2009. – N 94. – Р. 5023–5027.

Aydogan B. I., Sahin M. Adipocytokines in Thyroid Dysfunction // ISRN Inflammation. – 2013. – Vol. 2013. – Режим доступа к журн.: http://www.hindawi.com/isrn/inflammation/2013/646271/.

Ayturk S., Gursoy A., Kut A. et al. Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area // Eur. J. Endocrinol. – 2009. – Vol. 161. – P. 599–605.

Biondi B. Thyroid and Obesity: An Intriguing Relationship // The journal of clinical endocrinology and matabolism. – 2010. – Vol. 95, N 8. – Режим доступа: http://press.endocrine.org/doi/full/10.1210/jc.2010–1245.

Boelen A., Kwakkel J., Wiersinga W. M. et al. Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake // J. Endocrinol December. – 2006. – Vol. 191. – Р. 707–714.

Boelen A., Kwakkel J., Vos X. G. et al. Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor β2 mRNA expression in mice // J. Endocrinol. – 2006. – Vol. 190. – Р. 537–544.

Chopra I. J. A radioimmunoassay for measurement of 3,3'-diiodothyronine sulfate: Studies in thyroidal and nonthyroidal diseases, pregnancy, and fetal/neonatal life // Metabolism. – 2004. – Vol. 53, N 4. – Р. 538–543.

De Lloyd А., Bursell J., Gregory J. W. et al. TSH receptor activation and body composition // J. Endocrinol. – 2010. – Vol. 204. – P. 13–20.

De Vries E. M., Fliers E., Boelen A.The molecular basis of the non-thyroidal illness syndrome // J. Endocrinol. – 2015. – Vol. 225, N 3. – Р. 67–81.

Debaveye Y., Ellger B., Mebis L. et al. Tissue Deiodinase Activity during Prolonged Critical Illness: Effects of Exogenous Thyrotropin-Releasing Hormone and Its Combination with Growth Hormone-Releasing Peptide-2 // Endocrinology. – 2005. – Vol. 146, N 12. – Р. 5604–5611.

Dentice M., Salvatore D. Deiodinases: the balance of thyroid hormone: local impact of thyroid hormone inactivation // J. Endocrinol. – 2011. – Vol. 209, N 3. – P. 273–282.

Economidou F., Douka E., Tzanela M. et al. Thyroid function during critical illness // Hormones (Athens). – 2011. – Vol. 10, N 2. – Р. 117–124.

Farwell A. P. Nonthyroidal illness syndrome // Curr Opin Endocrinol Diabetes Obes. – 2013. – Vol. 20, N 5. – P. 478–484.

Fliers E., Guldenaar S. E. F. , Wiersinga W. M. et al. Decreased Hypothalamic Thyrotropin-Releasing Hormone Gene Expression in Patients with Nonthyroidal Illness // The J. of Clin. Endocrinol.& Metabolism December. – 1997. – Vol. 82, N 12. – Р. 4032–4036.

Fortes P. C., Carrero J. J., Hauser A. et al. Association between euthyroid sick syndrome and metabolic syndrome in dialysis patients // Perit. Dial. Int. – 2007. – Vol. 27, N 3. – Р. 11–27.

Galton V. A., Schneider М. J., Clark A. S. Life without thyroxine to 3,5,3′-triiodothyronine conversion: studies in mice devoid of the 5′-deiodinases // Endocrinology. – 2009. – Vol. 150, N 6. – Р. 2957–2963.

Katerina S. , Voidonikola P. , Stamatelopoulos K. et al. Association of thyroid function with arterial pressure in normotensive and hypertensive euthyroid individuals: A cross-sectional study // Thyroid Research. – 2008. – Vol. 1, N 3. – Р. 1186–1188.

Krotkiewski M. Krotkiewski M. Thyroid hormones in the pathogenesis and treatment of obesity // Eur. J. Pharmacol. – 2002. – Vol. 440, N 2–3. – Р. 85–98.

Kwakkel J., Chassande O., van Beeren H. C. Lacking thyroid hormone receptor β gene does not influence alterations in peripheral thyroid hormone metabolism during acute illness // J. Endocrinol. – 2008. – Vol. 197. – Р. 151–158.

Kwakkel J., Fliers E., Boelen A. Illness-induced changes in thyroid hormone metabolism: focus on the tissue level (review article) // Neth. J. Med. – 2011. – Vol. 69, N 5. – Р. 224–228.

Lado-Abeal J. Thyroid hormones are needed to sustain ”inappropriately” normal TSH during non-thyroidal illness syndrome: a clinical observation in severely ill patients with primary hypothyroidism // Neuroendocrin. Lett. – 2015. – Vol. 36, N 1. – P. 41–47.

Lado-Abeal J., Romero A., Castro-Piedras I. et al. Thyroid hormone receptors are down-regulated in skeletal muscle of patients with non-thyroidal illness syndrome secondary to non-septic shock // Eur. J. Endocrinol. – 2010. – Vol. 163, N 5. – Р. 765–773.

Larsen P. R., Zavacki A. M. Role of the Iodothyronine Deiodinases in the Physiology and Pathophysiology of Thyroid Hormone Action // Eur. Thyroid J. – 2012. – Vol. 1, N 4. – P. 232–242.

Lee Y. K. , Kim J. E. , Oh H. J. et al. Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome // Korean J. Intern. Med. – 2011. – Vol. 26, N 4. – Р. 432–439.

Légrádi G., Emerson C. H., Ahima R. S. et al. Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus // Flier Endocrinology. – 1997. – Vol. 138, N 6. – Р. 2569–2576.

Mancini A., Di Segni C., Raimondo S. et al. Thyroid Hormones, Oxidative Stress, and Inflammation // Mediators of Inflammation. – 2016. – Режим доступа: http://dx.doi.org/10.1155/2016/6757154.

Mebis L., Debaveye Y. , Ellger B. et al. Changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness // Crit. Care. – 2009. – Vol. 13, N 5. – Р. 147.

Mebis L., Paletta D., Debaveye Y. et al. Expression of thyroid hormone transporters during critical illness // Eur. J. Endocrinol. – 2009. – Vol. 161. – Р. 243–250.

Mebis. L., Van den Berghe G. Thyroid axis function and dysfunction in critical illness // Clin. Endocrinol. & Metabolism. – 2011. – Vol. 25, N 5. – P. 745–757.

Nagaya T., Fujieda M., Otsuka G. et al. A potential role of activated NF-κB in the pathogenesis of euthyroid sick syndrome // J. Clin. Invest. – 2000. – Vol. 106, N 3. – Р. 393–402.

Peeters R. P. , Geyten S. V. , Wouters P. J. et al. Tissue thyroid hormone levels in critical illness // J. Clin. Endocrinol. Metab. – 2005. – N 12. – Р. 6498–6507.

Rezzonico J., Rezzonico M., Pusiol E. et al. Introducing the thyroid gland as another victim of the insulin resistance syndrome // Thyroid. – 2008. – Vol. 18. – P. 461–464.

Roos A., Bakker S. J. L., Links T. P. et al. Thyroid Function Is Associated with Components of the Metabolic Syndrome in Euthyroid Subjects // The J. of Clin. Endocrinol. & Metabolism February. – 2007. – Vol. 92, N 2. – Р. 491–496.

Silvestri E., Lombardi A., de Lange P. et al. Age-related changes in renal and hepatic cellular mechanisms associated with variations in rat serum thyroid hormone levels // Endocrinol. аnd мetabolism. – 2008. – Vol. 294, N 6. – Р. 1160–1168.

Stabouli S., Papakatsika S., Kotsis V. Hypothyroidism and Hypertension: Mechanisms of Hypothyroidism-related Hypertension / S. Stabouli // Expert. Rev. Cardiovasc. Ther. – 2010. – Vol. 8, N 11. – P. 1157–1163.

Trajkovic M., Visser T. J., Mittag J. et al. Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8 // J. Clin. Invest. – 2007. – Vol. 117, N 3. – Р. 627–635.

Tsiotra P. C. , Boutati E., Dimitriadis G. et al. High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells // BioMed. Research. International. – 2013. – Vol. 2013. – Режим доступа к журн.: http://dx.doi.org/10.1155/2013/487081.

Vanhorebeek I., Van den Berghe G. The Neuroendocrine Response to Critical Illness is a Dynamic Process // Crit. Care Clin. – 2006. – Vol. 22. – P. 1–15.

Wajner S., Goemann L. M., Bueno A. L. IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells // The J. of Clin. Investigation. – 2011. – Vol. 121, N 5. – P. 1834–1845.

Warner M. H., Beckett G. J. Mechanisms behind the non-thyroidal illness syndrome: an update // J. Endocrinol. April. – 2010. – Vol. 205. – Р. 1–13.

Williams G. R., Duncan Bassett J. H. Local control of thyroid hormone action: role of type 2 deiodinase Deiodinases: the balance of thyroid hormone // J. of Endocrinol. – 2011. – Vol. 209. – P. 261–272.

Wittmann G., Harney J. W., Singru P. S. et al. Inflammation-inducible type 2 deiodinase expression in the leptomeninges, choroid plexus, and at brain blood vessels in male rodents // Endocrinology. – 2014. – Vol. 155. – P. 2009–2019.

Yu J., Koenig R. J. Induction of type 1 iodothyronine deiodinase to prevent the nonthyroidal illness syndrome in mice // Endocrinol. – 2006. – Vol. 147, N 7. – Р. 3580–3585.

Current views on nonthyroidal illness syndrome in clinical practice

Abstract

Downloads

References