Possibilities of chronotherapy of diseases of the nervous system

Keywords: circadian rhythms; desynchronosis; melatonin; chronopharmacology.

Abstract

Violations of the physiological rhythms of the nervous system are pathologically associated with the emergence of anxiety, depression, obsessive-compulsive disorder, insomnia, and other psychopathologies. Knowledge of the rhythmic nature of the nervous activity and the dependence of its disturbance on its desynchronization requires therapy with chronopharmacorrectors. Chronotherapy expands the possibilities of carrying out individual treatment of the patient, taking into account the physiological rhythms of the body. Recently obtained evidence of the chronopharmacological features of the action of neurotropic drugs and their ability to limit dysrhythmias in the body create new and adequate prospects for the treatment of the nervous system thanks to the restoration and correction of biological rhythms of nervous disorders caused by rhythm destabilizing effects. The article describes the chronopharmacological properties of melatonin, its role in regulating the body’s biorhythms, and the features of chronotherapy for the disorganization of the nervous system, taking into account the chronopharmacological properties of neurotropic agents. Literature data obtained from the search on PubMed and Google Scholar platforms were analyzed.

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Published
2022-09-25
How to Cite
Drohovoz, S. M., Shtroblia, A. L., Ivantsyk, L. B., ShchоkinaK. G., Lutsenko, R. V., Shtroblia, M. V., Lutsenko, O. A., Shtroblia, V. V., Belik, G. V., & Vashkeba-Bitler, E. M. (2022). Possibilities of chronotherapy of diseases of the nervous system. Likars’ka Sprava, (5-6), 14–24. https://doi.org/10.31640/2706-8803-2022-(5-6)-02
Section
Neurology