Keywords: actinic keratosis; solar keratosis; senile keratosis; precancerous skin lesion; chronic photodamage; squamous cell carcinoma in situ; solar radiation; ultraviolet; actinic cheilitis.


The article summarizes information about actinic keratosis, presents modern literature data on the epidemiology of the disease, the features of the clinical picture, diagnosis, differential diagnosis, therapy of the disease.


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Abramova, Т. V., Murakhovskaya, Е. К., Kovaleva, Yu. P. (2019). Actinic keratosis: аctual view. Vestnik Dermatologii i Venerologii, 95(6), 5–13. [Russian].

Azizov, B. S., Аliev, А. Sh., Agzamkhodzhayeva, S. S., Nurmatova, I. B., & Solmetova, М. А. (2018). К диагностике бугоркового кожного лейшманиоза. Stomatologiya, (2), 79–82. [Russian].

Azizov, B., Ismailova, G., Nabiev, F., Nurmatova, I., & Usmanov, A. Clinical characteristics of patients with HIV/AIDS. Tashkent: «Maxliyo-shifo» & V, 46.

Bäckvall, H., Asplund, A., Gustafsson, A. et al. (2005). Genetic tumor arche­ology: microdissection and genetic heterogeneity in squamous and basal cell carcinoma. Mutation Research, 571(1–2), 65–79.

Beasley, K. L., Weiss, R. A. (2014). Radiofrequency in cosmetic dermatology. Dermatologic Clinics, 32(1), 79–90.

Berry, K., Butt, M., Kirby, J. S. (2017). Influence of information framing on patient decisions to treat actinic keratosis. JAMA Dermatology, 153(5), 421–426.

Bobyr, I., Campanati, A., Consales, V. (2017). Ingenol mebutate in actinic keratosis: a clinical, videodermoscopic and immunohistochemical study. JEADV, 31(2), 260–266.

Chen, G. J., Feldman, S. R., Williford, P. M. et al. (2005). Clinical diagnosis of actinic keratosis identifies an elderly population at high risk of developing skin cancer. Dermatologic Surgery, 31(1), 43–47.

Copcu, E., Sivrioglu, N., Culhaci, N. (2004). Cutaneous horns: are these le­sions as innocent as they seem to be? World Journal of Surgical Oncology, 2, 18.

Criscione, V. D., Weinstock, M. A., Naylor, M. F. et al. (2012). Actinic keratoses: natural history and risk of malignant transformation in the Veterans Affairs topical tretinoin chemoprevention trial. Cancer, 115, 2523–2530.

De Olivera, E. C. V., da Motta, V. R. V., Pantoja, P. C. et al. (2019). Actinic keratosis – review for clinical practice. International Journal of Dermatology, 58(4), 400–407.

Dreno, B., Amici, J. M., Basset-Seguin, N. et al. (2014). Management of actinic keratosis: a practical report and treatment algorithm from AKTeam expert clinicians. JEADV, 28, 1141–1149.

Feldman, S. R., Fleischer A. B. (2011). Progression of actinic keratosis to squamous cell carcinoma revisited: clinical and treatment implications. Cu­tis, 87(4), 201–207.

Freeman, R. G. (1968). Carcinogenic effects of solar radiation and prevention measures. Cancer, 21(6), 1114–1120.;2-G

Goldenberg, G. (2017). Treatment considerations in actinic keratosis. JEADV, 31(S2), 12–16.

Gupta A. K., Paquet M., Villanueva E., Brintnell W. Interventions for actinic keratoses. Cochrane Database of Systematic Reviews. 2012. 12. P. CD004415.

Kaprin, A. D., Starinsky, V. V., Petrova, G. V. The status of cancer care for the population of Russia in 2017. M., 2018. 236 p. [Russian].

Kiryakov, D. A., Ganiev, A. A., Azizov, B. S., Nurmatova, I. B., Latipov, I. I. (2021). Epidemiology of malignant neoplasms among residents of the Tashkent region. Web of Scientist: International Scientific Research Journal, 2(11), 342–346.

Nurmatova, I. B. (2021). Применение лазерных технологий в лечении онихомикоза. Vestnik Dermatologii i Venerologii, 3, 39–41. [Russian].

Khlebnikova, A. N., Bobrov, M. A., Selezneva, E. V., Changlyan, K. A. (2012). Morphological features of actinic keratosis. Russian Journal of Skin and Venereal Diseases, 2, 10–15. [Russian].

Khleb­nikova, A. N., Obydenova, et al. (2017). Diagnosis of actinic keratosis by dermatoscopy. Vestnik dermatologii i venerologii, (2), 45–52. [Russian].

Kelman, Z. (1997). PCNA: structure, function and interactions. Oncogene, 14, 629–640.

McBride, P., Neale, R., Pandeya, N., & Green, A. (2007). Sun-related factors, beta papillomavirus, and actinic keratoses: a prospective study. Archives of Dermatology, 143(7), 862–868.

Pacifici, R. E., Davies, K. J. A. (1991). Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. Gerontology, 37(1-3), 166-180.

Padilla, R. S., Sebastian, S., Jiang, Z. et al. (2010). Gene expression pat­terns of normal human skin, actinic keratosis and squamous cell carci­noma. Archives of Dermatology, 146(3), 288–293.

Parrish, J. A. (2005). Immunosuppression, skin cancer, and ultraviolet A radiation. New England Journal of Medicine, (353), 2712–2713.

Park, H., Kim, W., Kim, H., & Yeo, H. (2016). Cutaneous horn in premalignant and malignant conditions. Archives of Craniofacial Surgery, 17(1), 25–27.

Pellacani, G., Peris, K., Guillen, C. et al. (2015). A randomized trial com­paring simultaneous vs. sequential field treatment of actinic keratosis with ingenol mebutateon two separate areas of the head and body. JEADV, 29(11), 2192–2198.

Pellacani, G., Ulrich, M., Casari, A. et al. (2015). Grading keratinocyteatypia in actinic keratosis: a correlation of reflectance confocal microscopy and histopathology. JEADV, 29(11), 2216–2221.

Peris, K., Calzavara-Pinton, P. G., & Neri L. (2016). Italian expert consen­sus for the management of actinic keratosis in immunocompetent patients. JEADV, 30(7), 1077–1084.

Peris, К., Micantonio, T., Piccolo, D. et al. (2007). Dermoscopic features of actinic keratosis. Journal der Deutschen Dermatologischen Gesellschaft, 5(11), 970–976.

Plasmeijer, E. I., Neale, R. E., & Buettner, P. G. (2010). Betapapillomavirus infection profiles in tissue sets from cutaneous squamous cell-carcinoma patient. International Journal of Cancer, 126(11), 2614–2621.

Pomerantz, H., Hogan, D., Eilers, D. et all. (2015). Long-term efficacy of topical fluorouracil cream, 5 %, for treating actinic keratosis: a randomized clinical trial. JAMA Dermatology, 151(9), 952–960.

Quaedvlieg, P. J., Tirsi, E., Thissen, M. R., & Krekels, G. A. (2006). Actinic keratosis: how to differentiate the good from the bad ones. European Journal of Dermatology, 16(4), 335–339. PMID: 16935787

Rosen, R. H., Gupta, A. K., & Tyring, S. K. (2012). Dual mechanism of ac­tion of ingenol mebutate gel for topical treatment of actinic keratoses: rapid lesion necrosis followed by lesion-specific immune response. JAAD, 66(3), 486–493.

Schmitz, L., Kahl, P., Majores, M. et al. (2016). Actinic keratosis: cor­relation between clinical and histological classification systems. JEADV, 30(8), 1303–1307.

Seyed Jafari, S. M., Timchik, T., & Hunger, R. E. (2016). In vivo confocal mi­croscopy efficacy assessment of daylight photodynamic therapy in actinic keratosis patients. JEADV, 175(2), 375–381.

Strunk, T., Braaten, L. R., & Szeimies, R. M. (2014). Actinic keratosis – a literature review. Vestnik Dermatologii i Venerologii, (5), 42–52.

Tomas, D. (2009). Apoptosis, UV-radiation, precancerosis and skin tumor. Acta Medica Croatica, (63), Suppl. 2, 53–58.

Thomas, G. J., Herranz, P., Cruz, S. B., & Parodi, A. (2019). Treatment of ac­tinic keratosis through inhibition of cyclooxygenase-2: potential mechanism of action of diclofenac sodium 3 % in hyaluronic acid 2,5 %. Dermatologic Therapy, 32(3), e12800.

Tsvetkova, G. M., Getiding Z. M., la Poel G. (1983). Pathomorphology of the skin in senile pruritus. Vestnik Dermatologii i Venerologii, (8), 8–12.

Werner, R. N., Jacobs, A., Rosumeck, S. et al. (2015). Evidence and consensus based (S3) guidelines for the treatment of actinic keratosis – international league of dermatological societies in cooperation with the European dermatology forum. JEADV, 29(11), 2069–2079.

Zalaudek, I., Giacomel, J., Argenziano, G. et al. (2006). Dermoscopy of fa­cial nonpigmented actinic keratosis. British Journal of Dermatology, 155(5), 951–956.

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How to Cite
Ayubova, N. M., Nurmatova, I. B., Ayupova, S. T., & Azizov, B. S. (2022). CLINICAL, MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL ASPECTS OF ACTINIC KERATOSIS. Likars’ka Sprava, (3-4), 15-26.
Pathology. Literature review