Correction of imbalance of essentialaminoacids of blood plasma in Patients with stableangina

  • T. V. Bohdan Bogomolets National Medical University
  • D. A. Pliskevich Bogomolets National Medical University
  • V. V. Bohdan Bogomolets National Medical University
  • Yu. O. Моshkovska Bogomolets National Medical University
  • O. V. Savchenko Bogomolets National Medical University
Keywords: stable angina; amino acid; L-arginine; basic therapy.

Abstract

Introduction. Ischemic heart disease is the leading nosology calunit in the structure of cardiovascular diseases interms of disability and mortality among the population of Ukraine. The purpose. To improve the treatment of patients with stable angina by studying the effect of L-arginine on the balance of essential amino acids in blood plasma. Material and methods. It was examined 85 patients with stable angina. They were divided into two groups: group Ipatients received antianginal basic therapy, group II patients received basic antianginal therapy and L-arginine. The amino acid spectrum of patients' blood plasma was studied by ion-exchange liquid column chromatography, using an automatic amino acid analyzer T-339 Microtechna (Czech Republic, Prague). Results and discussion. In patients with stable angina who received basic therapy and L-arginine, in contrast to patients who received only basic therapy, plasma levels of arginine became normalized, which probably contributes to the synthesis of NO. The level of valine, leucine and isoleucine, which provide the synthesis of acyl-CoA and succinyl-CoA, became also normalized.Conclusion. Administration of L-arginine to patients with stable angina together with antianginal therapy helps to correct plasma amino acid imbalances, which is likely to effectively affect the course of the disease and prognosis.

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References

Bogdan T. V., Lizogub V. G. Metabolіzm amіnokislot pri mіokardial'nіj іshemії: Monografіya. – K.: DІA, 2016. – 207 p.

Gandzyuk V. A. Analіz zahvoryuvanostі na іshemіchnu hvorobu sercya v Ukraїnі // Ukr. kardіol. zhurn. – 2014. – № 3. – P. 45–52.

Zaval's'ka T. V. Nezamіnnі amіnokisloti sirovatki krovі u hvorih na stabіl'nu ta nestabіl'nu stenokardіyu // Dop. NAN Ukraїni. – 2015. – № 5. – P. 173–177.

Krasnenkova T. P., Evseenko A. S., Kuvshinova N. A. Effektivnost' primeneniya glicina v eksperimental'noj modeli ostroj ishemii miokarda // Med. zhurn. – 2014. – № 2. – P. 70–73.

Lizogub V. G., Zaval's'ka T. V., Bogdan V. V., ZHornichenko D. M. Zamіnnі amіnokisloti plazmi krovі u hvorih na stabіl'nu ta nestabіl'nu stenokardіyu // Dop. NAN Ukraїni. – 2015. – № 6. – P. 167–174.

Kuryata O. V., Grechanik M. M. Rol' L-argіnіnu v lіkuvannі sercevo-sudinnih zahvoryuvan': u fokusі – vibіr efektivnoї dozi // Zdorov’ya Ukraїni. – 2019. – Vip. 456, № 11. – P. 17–18.

Kuryata O. V., Sіrenko O. Yu. Vpliv L-argіnіnu aspartatu na endotelіal'nu funkcіyu sudin u pacієntіv z arterіal'noyu gіpertenzієyu v poєdnannі z revmatoїdnim artritom // Ukr. med. chasopis. – 2014.– Vip. 103, № 5. – P. 64–66.

Mihajlovs'ka N. S., Stecyuk І. O., Kulinich T. O., Lіsova O. O. Klіnіchna efektivnіst' zastosuvannya L-argіnіnu u hvorih na іshemіchnu hvorobu sercya ta metabolіchnij sindrom // Semejnaya medicina. – 2019. – № 2. – P. 59–65.

Severin E. S. Biohimiya: Ucheb. dlya vuzov. – M.: Gektarmedia, 2003. – 779 p.

Sin'keev M. S., Skvorcov Yu. I., Bogdanova T. M., Skvorcov K. Yu. Aminokisloty krovi v patogeneze i klinike ishemicheskoj bolezni serdca // Mezhdunar. zhurn. priklad. i fundament. issledovanij. – 2014. – № 11. – P. 480–484.

Shevchenko V. P. Klinicheskaya dietologiya. – M.: GEOTAR-Media, 2009. – 256 p.

Chotechuang N., Azzout-Mamiche D., Bos C. MTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat // Am. J. Physiol. Endocrinol. Metab. – 2009. – Vol. 297. – P. 1313–1323.

Mitrega K., Zorniak M., Varghese B. Beneficial effects of L-leucine and L-valine on arrhythmias, hemodynamics and myocardial morphology in rats // Pharm. Research. – 2011. – Vol. 64, N 9. – P. 218–225.

Valerio A., D’Antona G., Niosoli E. Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective // Aging. – 2011. – Vol. 3, N 5. – P. 464–478.

Yang Q., Yang J., Wu G. et al. Effects of taurine on myocardial cGmp/cAMPratio, antioxidant ability and ultrastructure in cardiac hypertrophy rats induced by isoproterenol // Adv. Exp. Med. Biol. – 2013. – Vol. 776. – Р. 217–229.


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Published
2021-06-30
How to Cite
Bohdan, T. V., Pliskevich, D. A., Bohdan, V. V., МоshkovskaY. O., & Savchenko , O. V. (2021). Correction of imbalance of essentialaminoacids of blood plasma in Patients with stableangina. Likars’ka Sprava, (3-4), 36-41. https://doi.org/10.31640/JVD.3-4.2021(4)
Section
Original investigations