Prognosis of the fetal distress in pregnant women with hypertensive disorders and hyperhomocyteinemia

  • N. A. Gaistruk Vinnitsa Nathional Memory University named after N. I. Pirogov, cathedra of Obstetrics and Gynecology N 2
  • O. O. Mazchenko Vinnitsa Nathional Memory University named after N. I. Pirogov, cathedra of Obstetrics and Gynecology N 2
  • A. N. Gaistruk Vinnitsa Nathional Memory University named after N. I. Pirogov, cathedra of Obstetrics and Gynecology N 2
  • I.V. Prolygina Vinnitsa Nathional Memory University named after N. I. Pirogov, cathedra of Obstetrics and Gynecology N 2
  • S.A. Tarasiuk Vinnitsa Nathional Memory University named after N. I. Pirogov, cathedra of Obstetrics and Gynecology N 2
Keywords: logistic regression; forecasting; hyperhomocyteinemia; fetal distress; hypertensive disorders; arterial hypertension.

Abstract

In the article the reisapresentation of mathematical prediction of fetal distress in pregnant women with hypertensive disorders and hyperhomocyteinemia. In the basis of the model, the factors that significantly affect the chance of an unfavorable course of pregnancy for a given group of women. The clinical significance of the prediction is necessary for the formation of a differentiated approach to the management of pregnancy, depending on the probability of perinatal complications resulting from the application of the model. The most important role belongs to the detection of factors, which preceding development distress of fatus and are accompanied by the presence of extragenital diseases and patology of pregnancy. All of these factors should be known, when evaluated prenatal fetal condition, placental function, determination of laboratory-instrumental research methods for pregnancy with hypertensive disorders. Based on the results of the research, the algorithm of examination of the pregnant women with fetus distress symptoms was created. Parametric criteria are described for the diagnosis of fetal distress based on the determination of the level of homocysteine and oxidative modifection of protein in the blood of pregnant women. The original metod of forecasting the development of the fetal distress in pregnant women with hypertension is proposed. The use of drugs with metabolic action has led to credibly positive results, namely the reduction of the incidence of fetal distress, asphyxiation of newborns and prenatal morbidity and mortality. As a result of this we can see an improvement in reproductive health of women with hypertensive disorders.

Downloads

Download data is not yet available.

References

Gajstruk N. A., Rud' V. O., Mazchenko O. O. Profіlaktika perinatal'nih uskladnen' gіpergomocisteїnemії u vagіtnih z gіpertenzivnimi rozladami // Zdorov'e zhenshchiny. – 2009. – № 3. – P. 50–54.

Gajstruk N. A., Mazchenko O. O., Nadєzhdіn M. V. ta іn. Profіlaktika ta lіkuvannyadistresu ploda і rannіh sudinnih porushen' u vagіtnih grupi riziku viniknennya gіpertenzivnih rozladіv // Biol. terapiya. – 2012. – № 2. – P. 42–46.

Gajstruk N. A., Mazchenko O. O. Nadєzhdіn M. V. Suchasnі aspekti dіagnostiki ta terapії distresu ploda і rannіh sudinnih porushen' u vagіtnih // Zdorov'e zhenshchiny. – 2012. – Vip. 74, № 8. – P. 98–101.

Gajstruk N. A., Mazchenko O. O. Razrabotka effektivnoj sistemy diagnostiki i profilaktiki distressa ploda putyom izucheniya metabolicheskih processov u beremennyh s gipertenzivnymi rasstrojstvami i placentarnoj nedostatochnost'yu // J. of Education, Health and Sport. – 2016. – Vol. 6, № 6. – P. 155–176.

Geryak S. M. Stan sistemi gemostazu u vagіtnihіz pre eklampsієyu // Vіsn. nauk. doslіdzhen'. – 2011. – № 2. – P. 89–90.

Gojda N. G. Derzhavna polіtika Ukraїni shchodo zberezhennya reproduktivnogo zdorov'ya // Pedіatrіya, akusherstvo і gіnekologіya. – 2004. – № 1. – P. 72–74.

Zhukova V. B., Protasov Yu. V., Gnіdenko K. Yu., Zelena І. І. Gіpergomocisteїnemіya: stan problemi // Suchasna gastroenterologіya. – 2006. – T. 27, № 1. – P. 87–92.

Lapach S. N., Gubenko A. V., Babich P. N. Statisticheskie metody v mediko-biologicheskih issledovaniyah s ispol'zovaniem EkheL. – K. MORION, 2001. – 408 p.

Rebrova O. Yu. Statisticheskij analiz medicinskih dannyh. Primenenie paketa prikladnyh programm STATISTICA. – M.: Media sfera, 2003. – 312 p.

Aksornphusitaphong A., Phupong V. Risk factors of early and late onset preeclampsiya // J. Obstet. Gynaecol. Res. – 2013. – Vol. 39, N 3. – P. 627–631.

Cotton D. B., Lee W., Huhta J. C., Dolman K. F. Hemodynamic profile in severe pregnancyinduced hypertension // Am. J. of Obstetrics and Gynecology. – 1988. – Vol. 158. – P. 523–529.

Dall’Asta A., Brunelly V., Frefumo F. et al. Early onset fetalgrows restriction // J. Perinat. Med. – 2010. – Vol. 30, N 2. – P. 412–417.

Kinzler W. L., Vintzileos A. M. Fetalgrowth restriction: a modern approach // Curr. Opin. Obstet. – 2008. – Vol. 20, N 2. – P. 125–131.


Abstract views: 85
PDF Downloads: 147
Published
2020-09-30
How to Cite
Gaistruk, N. A., Mazchenko, O. O., Gaistruk, A. N., Prolygina, I., & Tarasiuk, S. (2020). Prognosis of the fetal distress in pregnant women with hypertensive disorders and hyperhomocyteinemia. Likars’ka Sprava, (5-6), 61-72. https://doi.org/10.31640/JVD.5-6.2020(6)
Section
Guide lines for the practitioner