PECULIARITIES OF CLINICAL PASSING OF ATOPIC DERMATITIS AND VITAMIN D EXCHANGE IN EARLY CHILDREN

  • N. V. Kamut Danylo Halytsky National Medical University of Lviv, Department of Pediatrics and Neonatology Faculty of Postgraduate Education
  • M. M. Kiselova Danylo Halytsky National Medical University of Lviv, Department of Pediatrics and Neonatology Faculty of Postgraduate Education
Keywords: atopic dermatitis; children; vitamin D; 25-hydroxycholecalcipherol.

Abstract

The article is devoted to the study of features of clinical course of atopic dermatitis and vitamin D exchange in young children conducted by us by estimation of severity of atopic dermatitis depending on the value of SCORAD index, determination of 25(OH)D concentration in serum of children by immunochemical method with chemocentric analysis according to the classification approved by experts of the international endocrinological society. In the examination of 188 young children, two groups were formed on the basis of the Lviv City Children's Clinical Hospital. Children from 1 month to 1 year of age with manifestations of atopic dermatitis (n = 120), who were born full-term and had no birth defects, metabolic disorders, severe perinatal CNS lesions formed the main group. The comparison group consisted of 68 healthy young children without chronic diseases. All children had atopic dermatitis in the main group and were classified by severity (depending on the SCORAD index): children with mild severity – 31 (26 %), moderate 47 (39 %), and severe 42 (35 %). As a result of the study, we found a association between the severity of clinical manifestations of atopic dermatitis and the level of vitamin D in the serum. Comparative analysis of the severity of atopic dermatitis, depending on the level of vitamin D in the serum, showed that with severe atopic dermatitis in children of the main group, the level of 25(OH)D was significantly lower compared to its indicators in children with moderate to severe (P < 0.05). Serum vitamin D levels are significantly lower in all forms of atopic dermatitis severity and correlate significantly with the overall SCORAD severity score, erythema intensity, excoriation, itching, and sleep disturbances. The scientific data on the presence of feedback correlation (r = –0,48; P < 0,05) between the development of atopic dermatitis in children and their level of 25(OH)D in serum were added. Our findings suggest that there is a need for a differentiated approach to treating early-stage atopic dermatitis of varying severity, a personalized therapeutic approach to choosing a vitamin D supplementation, given the level of 25(OH)D in the serum.

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References

Allen K. J. Vitamin D insufficiency is associated with challenge-proven food allergy in infants // J. Allergy Clin. Immunol. – 2018. – Vol. 131. – P. 1109–1116.

Bischof M. G., Heinze G., Vierhapper H. Vitamin D status and its relation to age and body mass index // Horm. Res. – 2016. – Vol. 66, N 5. – P. 211–215.

Bischoff-Ferrari H. A., Giovannucci E., Willett W. C., Dietrich T. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes // Am. J. Clin. Nutr. – 2016. – Vol. 84, N 1. – P. 18–28.

Cashman K. D., Dowling K. G., Škrabáková Z. et al. Vitamin D deficiency in Europe: pandemic? // Am. J. Clin. Nutr. – 2016. – Vol. 103, N 4. – P. 1033–1044.

Cengiz Kara. Figen Gunindi, Ala Ustyol, Murat Aydin. Dosing Error With Over-the-Counter Vitamin D Supplement: A Risk for Vitamin D Toxicity in Infants // Clin. Pediatr. – 2013. – Vol. 52, N 1. – P. 82–85.

Chuyko M. M. The validity of the application needs of vitamin d in children of different ages which drug to choose? // Neonatology, surgery and perinatal medicine. – 2015. – Vol. 16, N 2. – P. 129–134.

Forrest K.Y., Stuhldreher W. L. Prevalence and correlates of vitamin D deficiency in US adults // Nutr. Res. – 2019. – Vol. 31. – P. 31–48.

Gordon C. M., Feldman H. A., Sinclair L. et al. Prevalence of vitamin D deficiency among healthy infants and toddlers // Arch. Pediatr. Adolesc. Med. – 2008. – Vol. 162, N 6. – P. 505–512.

Grotto D. T. Standard American Diet and Its Relationship to the Health Status of Americans // Nutr. Clin. Pract. – 2015. – Vol. 25, N 6. – P. 603–612.

Gupta A., Bush A., Hawrylowicz C., Saglani S. Vitamin D and asthma in children // Paediatr. Respir. Rev. – 2017. – Vol. 13. – P. 236–243.

Han T.Y., Kong T.S., Kim M.H. et al. Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis // Ann. Dermatol. – 2015. – Vol. 27, N 1. – P. 10–40.

Heaney R. P., Recker R. R., Grote J., Horst R. L. Vitamin D(3) is more potent than vitamin D(2) in humans // J. Clin. Endocrinol. Metab. – 2019. – Vol. 96, N 3. – P. 447–452.

Holmes E. W., Garbincius J., McKenna K. M. Analytical variability among methods for the measurement of 25-hydroxyvitamin D: still adding to the noise // Am. J. Clin. Pathol. – 2015. – Vol. 140. – P. 550–560.

Kamut N. V. Peculiarities of therapeutic and prophylactic measures in children of early age with phosphorus and calcium metabolism disorders // Med. and Clin. Chemistry. – 2018. – Vol. 4. – P. 17–23.

Mansbach J. M., Ginde A. A., Camargo C. A. Serum 25-hydroxyvitamin D levels among US children aged 1 to 11 years: do children need more vitamin D? // Pediatrics. – 2019. – Vol. 124. – P. 1404–1410.

Merewood Anne. Vitamin D Status among 4-Month-Old Infants in New England: A Prospective Cohort Study // J. Hum. Lact. – 2018. – Vol. 28, N 2. – P. 159–166.

Muehleisen B., Gallo R. L. Vitamin D in allergic disease: shedding light on a complex problem // J. Allergy Clin. Immunol. – 2019. – Vol. 131. – P. 324–329.

Murad M. H., Elamin K. B., Abu Elnour N. O. et al. Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis // J. Clin. Endocrinol. Metab. – 2011. – Vol. 96. – P. 2997–3006.

Elizabeth A. Yetley, Christine M. Pfeiffer, Rosemary L. Schleicher et al. NHANES Monitoring of Serum 25-Hydroxyvitamin D: A Roundtable Summary // J. Nutr. – 2010. – Vol. 140. – P. 2030–2045.

Rusinska A., Płudowski P., Walczak M. et al. Vitamin D supplementation guidelines for general population and groups at risk of vitamin d deficiency in poland-recommendations of the polish society of pediatric endocrinology and diabetes and the expert panel with participation of national specialist consultants and representatives of Scientific Societies-2018 Update // Front. Endocrinol. – 2018. – Vol. 9. – P. 246–256.

Saintonge S., Bang H., Gerber L. M. Implications of a new definition of vitamin D deficiency in a multiracial us adolescent population: the National Health and Nutrition Examination Survey III // Pediatrics. – 2016. – Vol. 123. – P. 797–823.

Science M., Maguire J. L., Russell M. L. et al. Low serum 25-hydroxyvitamin D level and risk of upper respiratory tract infection in children and adolescents // Clin. Infect. Dis. – 2017. – Vol. 57. – P. 392–404.

Sempos C. T., Vesper H. W., Phinney K. W. et al. Vitamin D status as an international issue: national surveys and the problem of standardization // Scand. J. Clin. Lab. Invest. Suppl. – 2019. – Vol. 234. – P. 232– 243.

Silverberg J. I. Public Health Burden and Epidemiology of Atopic Dermatitis // Dermatol. Clin. – 2017. – Vol. 35, N 3. – P. 283–289.

Vilarrasa N., Maravall J., Estepa A. et al. Low 25-hydroxyvitamin D concentrations in obese women: their clinical significance and relationship with anthropometric and body composition variables // J. Endocrinol. Invest. – 2017. – Vol. 30, N 8. – P. 653–658.

Von Hurst P. R., Stonehouse W., Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient – a randomised, placebo-controlled trial // Br. J. Nutr. – 2019. – Vol. 103. – P. 549–555.

Wen J., Kang C., Wang J. et al. Association of maternal serum 25-hydroxyvitamin D concentrations in second and third trimester with risk of macrosomia // Sci Rep. – 2018. – Vol. 8, N 1. – P. 61–69.

Wójcik M., Jaworski M., Pludowski P. 25(OH)D Concentration in Neonates, Infants, and Toddlers From Poland-Evaluation of Trends During Years 1981–2011 // Front. Endocrinol. (Lausanne). – 2018. – N 8 – P. 656–662.


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Published
2020-06-30
How to Cite
Kamut, N. V., & Kiselova, M. M. (2020). PECULIARITIES OF CLINICAL PASSING OF ATOPIC DERMATITIS AND VITAMIN D EXCHANGE IN EARLY CHILDREN. Likars’ka Sprava, (3-4), 27-35. https://doi.org/10.31640/JVD.3-4.2020(5)
Section
Original investigations