ESTIMATION OF EFFICIENCY OF VARIOUS SCHEMES OF THERAPY OF PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN – BARR

  • K. V. Yurko National Medical University
  • V. M. Kozko National Medical University
  • N. F. Merkulova National Medical University
  • О. I. Моhylenets National Medical University
Keywords: Epstein – Barr virus infectious mononucleosis; therapy.

Abstract

Background: Actuality of study of infectious mononucleosis (ІМ) is conditioned by high infected of population by the Epstein – Barr virus (EBV), specific virus affinity to the immunocompetent cells, lifelong virus persistence in an organism and often latent process. Methods: Research on the work topic was conducted at the Department of Infectious Diseases of Kharkiv National Medical University. A total of 45 patients with IM (26 men and 19 women) who were hospitalized at the Regional Clinical Hospital in 2018–2019 years were surveyed. The vast majority of patients with IM were young people aged from 18 to 25, of whom 597 % were students. Results: The clinical picture of infectious mononucleosis caused by the Epstein–Barr virus, mainly characterized by manifestations of hepatomegaly, lymphadenopathy, intoxication syndrome and nasopharyngeal tonsillitis. The efficacy of combined use of Valacyclovir and Nuclex in complex therapy of patients with infectious mononucleosis caused by Epstein – Barr virus (EBV) was studied. The use of such therapy was found to promotes regression of clinical symptoms, contribute to normalization of indices of clinical blood tests and lead to a decrease of the number of EVB's DNA copies in the blood serum or complete elimination of virus. Conclusions: Thus, evaluation of the effectiveness of the use of valacyclovir and nuclex in the complex therapy of patients with infectious mononucleosis caused by Epstein–Barr virus, indicates a more significant regression of clinical symptoms, significantly more pronounced positive impact on the indicators of clinical blood analysis and the number of copies of EBV DNA in blood serum than in the comparison group. Obtained results allowed to substantiate the use of complex therapy of valacyclovir and nuclex in patients with IM caused by EBV.

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Published
2019-12-31
How to Cite
Yurko, K. V., Kozko, V. M., Merkulova, N. F., & МоhylenetsО. I. (2019). ESTIMATION OF EFFICIENCY OF VARIOUS SCHEMES OF THERAPY OF PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN – BARR. Likars’ka Sprava, (7-8), 41-45. https://doi.org/10.31640/JVD.7-8.2019(6)
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