Furoxan influence on excretory renal function on the background of water loads

  • E. A. Duchenko Kharkiv State Zooveterinary Academy
  • V. I. Kornienko Kharkiv State Zooveterinary Academy
  • E. V. Ladogubets Kharkiv State Zooveterinary Academy
  • S. M. Drogovoz National University of Pharmacy, Kharkiv
Keywords: saluretiks; furoxan; excretory function of the kidneys

Abstract

Furoxan use on a background water load is investigated, saluretic effect of the drug is revealed. Furoxan enhances glomerular filtration, increases the excretion of sodium ions and evinces less potassium- uretic activity. Furoxan application did not reveal significant changes in parameters of kidney function and protein excretion. Furoxan is an effective substance with diuretic properties that promising for further research its specific activity to create an effective diuretic drug.

Downloads

Download data is not yet available.

References

1. Bogolepova A. E., Natochin Yu. V. Fiziologicheskij analiz funkcii pochki pri razlichnyh tipah diureza // Nefrologiya. – 2005. – T. 9, № 2. – S. 9–15.
2. Bryuhanov V. M., Zverev Ya. F., Lampatov V. V. i dr. Metodicheskie podhody k izucheniyu funkcii pochek v єksperimente na zhivotnyh // Nefrologiya. – 2009. – T. 13, № 3. – S. 52–62.
3. Gozhenko A. I., Zhigalina–Gricenyuk M. S. Preventivnye mekhanizmy regulyacii vodno-solevogo obmena skvoz' prizmu teorii funkcional'nyh sistem // Bukov. med. vіsn. – 2012. – T. 16, Vyp. 63, № 3, Ch. 2. – S. 80–83.
4. Drogovoz S. M., Gudzenko A. P., Butko Ya. A. ta іn. Pobochnoe dejstvie lekarstv. – H.: SIM, 2010. – 480 s.
5. Duchenko K. A., Kornієnko V. І., Samura B. A. ta іn. Doslіdzhennya gostroї toksichnostі ta dіuretichnoї aktivnostі 7-(2-gіdroksi-3-p-metoksifenoksi)-propіl-8-zamіshchenih teofіlіnu // Eksperim. і klіn. medicina. – 2015. – Vip. 69, № 4. – S. 21–24.
6. Doklіnіchnі doslіdzhennya lіkars'kih zasobіv: Metod. rekomendacії / Za red. O. V. Stefanova. – K.: Avіcena, 2001. – 528 c.
7. Lapach S. N., CHubenko A. V., Babich P. N. Statistika v nauke i biznese. – K.: Morion, 2002. – 640 s.
8. Mashkovskij M. D. Lekarstvennye sredstva. – 15-e izd., pererab., ispr. i dop. – M.: OOO Izd-vo Novaya volna, 2008. – 1206 s.
9. Romanenko N. I., Kornienko V. I., Pakhomova O. A. et al. Synthesis, physicalche-mical and biological properties of 8-aminosubstituted 7-β-hydroxy (oxo)alkyl (aryl)-xanthenes // X-th International Symposium on the Chemistry of Natural Compounds Nov. 2013. – Tashkent-Bukhara, Republic of Uzbekistan. – P. 269.

Abstract views: 124
PDF Downloads: 122
Published
2018-06-27
How to Cite
Duchenko, E. A., Kornienko, V. I., Ladogubets, E. V., & Drogovoz, S. M. (2018). Furoxan influence on excretory renal function on the background of water loads. Likars’ka Sprava, (5-6), 127-130. https://doi.org/10.31640/JVD.5-6.2018(22)
Section
Experimental researches