Clinical significance of biomarkers of osteochondral lesions in early rheumatoid arthritis

  • D. G. Rekalov Zaporozhye State Medical University
  • A. V. Prytkova Zaporozhye State Medical University
Keywords: early rheumatoid arthritis, regression analysis, subchondral erosion, bone and cartilage lesions, biomarkers


Studied biomarkers of osteochondral lesions on early stages of rheumatoid arthritis (RA). The data shown the prognostic value of indicators of the erosive and destructive changes of joints in early and in the advanced stage of RA. Analyzed indicators that determine how directly, inflammatory process activity and markers associated with the speed and staging damaged articular surfaces that can adequately justify individualized clinical strategy in patients with early RA.


Download data is not yet available.


1. Arnett F. C., Edworthy S. M., Bloch D. A. et al. The ARA 1987 revised criteria for the classification of rheumatoid arthritis // Arthritis Rheum. –1988. –Vol. 31. – P. 315–324.
2. De Hair M. J., van de Sande M. G., Ramwadhdoebe T. H. et al. Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis // Arthritis Rheum. – 2014. – Vol. 66. – P. 513–522.
3. Gilkeson G., Polisson R., Sinclair H. et al. Early detection of carpal erosions in patients with rheumatoid arthritis: a pilot study of magnetic resonance imaging // J. Rheumatol. – 1988. – Vol. 15. – P. 1361–1366.
4. Harre U., Lang S. C., Pfeifle R. et al. Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss // Nat. Commun. – 2015. – Vol. 6. – P. 6651.
5. Harre U., Georgess D., Bang H. et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin // J. Clin. Invest. – 2012. –Vol. 122. – P. 1791–1802.
6. Kleyer A., Schett G. Arthritis and bone loss: a hen and egg story // Curr. Opin. Rheumatol. – 2014. – Vol. 26. – P. 80–84.
7. Kopesky P., Tiedemann K., Alkekhia D. et al. Autocrine signaling is a key regulatory element during osteoclastogenesis // Biol. Open. – 2014. – Vol. 3. – P. 767–776.
8. Kleyer A., Finzel S., Rech J. et al. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies // Ann. Rheum. Dis. –2014. – Vol. 73. – P. 854–860.
9. Klareskog L, Catrina A.I., Paget S. Rheumatoid arthritis // Lancet. – 2009. – Vol. 373. – P. 659–672.
10. Kotake S., Sato K., Kim K. J. et al. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation // J. Bone Miner. Res. – 1996. – Vol. 11. – P. 88–95.
11. Marinova-Mutafchieva L., Williams R. O., Funa K. et al. Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis // Arthritis Rheum. – 2002. – Vol. 46. – P. 507–513.
12. McQueen F. M., Stewart N., Crabbe J. et al. Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months after symptom-onset // Ann. Rheum. Dis. – 1998. – Vol. 57. – P. 350–356.
13. Molenaar E. T., Voskuyl A. E., Dinant H. J. et al. Progression of radiologic damage in patients with rheumatoid arthritis in clinical remission // Arthritis Rheum. – 2004. –Vol. 50. – P. 36–42.
14. Nielen M. M. J., van Schaardenburg D., Reesink H. W. et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors // Arthritis Rheum. – 2004. – Vol. 50. – P. 380–386.
15. Syversen S. W., Goll G. L., van der Heijde D. et al. Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study // Ann. Rheum. Dis. – 2010. – Vol. 69. – P. 345–351.
16. Souza P. P., Lerner U. H. The role of cytokines in inflammatory bone loss // Immunol. Invest. – 2013. – Vol. 42. – P. 555–622.
17. Schellekens G. A., Visser H., de Jong B. A. et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide // Arthritis Rheum. – 2000. – Vol. 43. –P. 155–163.
18. Smolen J. S., Sokka T., Pincus T., Breedveld F. C. A proposed treatment algorithm for rheumatoid arthr itis: aggressive therapy, methotrexate and quantitative measures // Clin. Exp. Rheumatol. – 2003. – Vol. 21 (Suppl. 31). – P. 209–210.
19. Van Boekel M. A., Vossenaar E. R., van den Hoogen F., van Venrooij W. J. Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value // Arthritis Res. – 2002. – Vol. 4. – P. 87–93.
20. Van der Heijde D. M., Jacobs J. W. The original "DAS" and the "DAS28" are not interchangeable: comment on the articles by Prevoo et al. // Arthritis Rheum. – 1998. – Vol. 41 (Suppl. 5). – P. 942–945.
21. Van der Helm-van Mil A. H., Verpoort K. N., Breedveld F. C. et al. Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis // Arthritis Res. Ther. – 2005. – Vol. 7. – P. 949–958.
22. Verstrepen L., Bekaert T., Chau T. L. et al. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme" // Cellular and molecular life sciences. –2008. – Vol. 65 (Suppl. 19). – P. 2964–2978.
23. Vossenaar E. R., Smeets T. J. M., Kraan M. C. et al. The presence of citrullinated proteins is not specific for rheumatoid synovial tissue // Arthritis Rheum. – 2004. –Vol. 50. – P. 3485–3494.

Abstract views: 100
PDF Downloads: 59
How to Cite
Rekalov, D. G., & Prytkova, A. V. (2018). Clinical significance of biomarkers of osteochondral lesions in early rheumatoid arthritis. Likarsʹka Sprava, (3-4), 98-104.
Original intestigations