Endothelial injury in children with acute infectious diseases and its evaluation using biomarker E-selectin

  • V. V. Yevtushenko O. O. Bogomolets National Medical University named
  • S. O. Kramarov O. O. Bogomolets National Medical University named
  • V. O. Shadrin O. O. Bogomolets National Medical University named
  • L. V. Zarkodonets O. O. Bogomolets National Medical University named
Keywords: infectious diseases, endothelium, endothelial dysfunction, biomarker, E-selectin, children

Abstract

A pilot study of endothelial injury biomarker E-selectin value among 55 children with acute infectious diseases of different etiology was conducted. E-selectin level correlated significantly with the presence of septic shock (Rpb = 0.35; P  = 0.003) and acute phase inflammatory reactant, C-reactive protein (R = 0.43; P  = 0.001). The level of E-selectin did not have a statistical association with age of patients (R = –0.197; P  = 0.369), the sex of patients (Rpb = 0.08; P  = 0.585), treatment in the intensive care unit (Rpb = 0.13; P  = 0,203), mechanical ventilation (Rpb = 0,27; P  = 0,208), duration of inpatient treatment (R = 0,043; P  = 0,845), serum LDH level (R = –0,09; P  = 0,49), serum lactate (R = –0.015; P  = 0.945) and blood leukocyte levels (R = 0.153; P  = 0.475).

Downloads

Download data is not yet available.

References

1. Amalakuhan B., Habib S.A., Mangat M., Reyes L.F., Rodriguez A.H., Hinojosa C.A., et al. Endothelial adhesion molecules and multiple organ failure in patients with severe sepsis // Cytokine. 2016. (88). C. 267–273.
2. Armstrong S.M., Darwish I., Lee W.L. Endothelial activation and dysfunction in the pathogenesis of influenza A virus infection. // Virulence. 2013. № 6 (4). C. 537–42.
3. Balabanov R., Goldman H., Murphy S., Pellizon G., Owen C., Rafols J., et al. Endothelial cell activation following moderate traumatic brain injury // Neurological Research. 2001. № 2–3 (23). C. 175–182.
4. Conroy A.L., Lafferty E.I., Lovegrove F.E., Krudsood S., Tangpukdee N., Liles W.C., et al. Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria // Malaria Journal. 2009. № 1 (8). C. 295.
5. Coureuil M., Join-Lambert O., Lécuyer H., Bourdoulous S., Marullo S., Nassif X. Mechanism of meningeal invasion by Neisseria meningitidis // Virulence. 2012. № 2 (3). C. 164.
6. Edgar J.D.M., Gabriel V., Gallimore J.R., McMillan S.A., Grant J. A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection. // BMC pediatrics. 2010. (10). C. 22.
7. El-Sayed M.H., Shanab G., Karim A.M., el-Tawil A., Black A., Dixon J.S. Lamivudine facilitates optimal chemotherapy in hepatitis B virus-infected children with hematological malignancies: a preliminary report. // Pediatric hematology and oncology. 2004. № 2 (21). C. 145–56.
8. Fukuda H., Tsuchida D., Koda K., Miyazaki M., Pappas T.N., Takahashi T. Inhibition of sympathetic pathways restores postoperative ileus in the upper and lower gastrointestinal tract // Journal of Gastroenterology and Hepatology. 2007. № 8 (22). C. 1293–1299.
9. Khongphatthanayothin A., Phumaphuti P., Thongchaiprasit K., Poovorawan Y. Serum levels of sICAM-1 and sE-selectin in patients with dengue virus infection. // Japanese journal of infectious diseases. 2006. № 3 (59). C. 186–8.
10. Ku C-C., Besser J., Abendroth A., Grose C., Arvin A.M. Varicella-Zoster Virus Pathogenesis and Immunobiology: New Concepts Emerging from Investigations with the SCIDhu Mouse Model // Journal of Virology. 2005. № 5 (79). C. 2651–2658.
11. Leligdowicz A., Conroy A.L., Hawkes M., Shiboski S., Zhong K., Namasopo S., et al. Markers of Endothelial Injury and Immune Activation Effectively Risk-Stratify Acute Febrile Syndromes in African Children 2017. A2818–A2818 с.
12. Lovegrove F.E., Tangpukdee N., Opoka R.O., Lafferty E.I., Rajwans N., Hawkes M., et al. Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African Children // PLoS ONE. 2009. № 3 (4). C. e4912.
13. Nevard C.H., Blann A.D., Jurd K.M., Haycock G.B., Hunt B.J. Markers of endothelial cell activation and injury in childhood haemolytic uraemic syndrome. // Pediatric nephrology (Berlin, Germany). 1999. № 6 (13). C. 487–92.
14. De Pablo R., Monserrat J., Reyes E., Díaz D., Rodríguez-Zapata M., De la Hera, A., Prieto A. VCirculating sICAM-1 and sE-Selectin as biomarker of infection and prognosis in patients with systemic inflammatory response syndrome // European Journal of Internal Medicine. 2013. № 2 (24). C. 132–138.
15. Page A. V, Liles W.C. Biomarkers of endothelial activation/dysfunction in infectious diseases // Virulence. 2013. № 6 (4). C. 507–516.
16. Paize F., Sarginson R., Makwana N., Baines PB., Thomson A.P.J., Sinha I., et al. Changes in the sublingual microcirculation and endothelial adhesion molecules during the course of severe meningococcal disease treated in the paediatric intensive care unit // Intensive Care Medicine. 2012. № 5 (38). C. 863–871.
17. Sosa-Bustamante G.P., Amador-Licona N., Barbosa-Sabanero G., Guízar-Mendoza J.M., López-Briones S., Mulgado-Aguas C.I., et al. Intercellular adhesion molecules and mortality for sepsis in infants younger than 1 year of life. // Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion. № 6 (63). C. 601–6.
18. Tchinda V.H.M., Tadem A.D., Tako E.A., Tene G., Fogako J., Nyonglema P., et al. Severe malaria in Cameroonian children: correlation between plasma levels of three soluble inducible adhesion molecules and TNF-α // Acta Tropica. 2007. № 1 (102). C. 20–28.
19. Zanoni I., Ostuni R., Marek L.R., Barresi S., Barbalat R., Barton G.M., et al. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. // Cell. 2011. № 4 (147). C. 868–80.

Abstract views: 159
PDF Downloads: 144
Published
2018-12-05
How to Cite
Yevtushenko, V. V., Kramarov, S. O., Shadrin, V. O., & Zarkodonets, L. V. (2018). Endothelial injury in children with acute infectious diseases and its evaluation using biomarker E-selectin. Likars’ka Sprava, (3-4), 68-73. https://doi.org/10.31640/3-4.2018(10)
Section
Original investigations