Endothelial injury in children with acute infectious diseases and its evaluation using biomarker E-selectin

  • V. V. Yevtushenko O. O. Bogomolets National Medical University named
  • S. O. Kramarov O. O. Bogomolets National Medical University named
  • V. O. Shadrin O. O. Bogomolets National Medical University named
  • L. V. Zarkodonets O. O. Bogomolets National Medical University named
Keywords: infectious diseases, endothelium, endothelial dysfunction, biomarker, E-selectin, children

Abstract

A pilot study of endothelial injury biomarker E-selectin value among 55 children with acute infectious diseases of different etiology was conducted. E-selectin level correlated significantly with the presence of septic shock (Rpb = 0.35; P  = 0.003) and acute phase inflammatory reactant, C-reactive protein (R = 0.43; P  = 0.001). The level of E-selectin did not have a statistical association with age of patients (R = –0.197; P  = 0.369), the sex of patients (Rpb = 0.08; P  = 0.585), treatment in the intensive care unit (Rpb = 0.13; P  = 0,203), mechanical ventilation (Rpb = 0,27; P  = 0,208), duration of inpatient treatment (R = 0,043; P  = 0,845), serum LDH level (R = –0,09; P  = 0,49), serum lactate (R = –0.015; P  = 0.945) and blood leukocyte levels (R = 0.153; P  = 0.475).

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Published
2018-12-05
How to Cite
Yevtushenko, V. V., Kramarov, S. O., Shadrin, V. O., & Zarkodonets, L. V. (2018). Endothelial injury in children with acute infectious diseases and its evaluation using biomarker E-selectin. Likarsʹka Sprava, (3-4), 68-73. https://doi.org/10.31640/3-4.2018(10)
Section
Original intestigations