Indicators of local immunity in women with percistant form of latent papillomavirus cervical infection after immunization with vaccine against HPV

  • O. L. Dola Перинатальний центр Києва
  • V. P. Lakatosh Кафедра акушерства та гінекології 1 (зав. – проф. Б. М. Венцківський) Національного медичного університету ім. О. О. Богомольця
  • M. I. Antonuk Кафедра акушерства та гінекології 1 (зав. – проф. Б. М. Венцківський) Національного медичного університету ім. О. О. Богомольця
  • P. V. Lakatosh Кафедра акушерства та гінекології 1 (зав. – проф. Б. М. Венцківський) Національного медичного університету ім. О. О. Богомольця
Keywords: papillomavirus infection, cervix, local immunity, vaccination

Abstract

In this study, the changes in the local immunity indices were detected across one and six months after CervarixТМ vaccination of 35 women with diagnosed persistent latent papillomavirus infection (PVI) of the cervix uteri (CU). Under the influence of HPV-vaccination, after 6 months was noted the desire to normalization of indices, characterizing local immunity in women with latent PVI CU – of the level in the cervical separable sIgA, α- and g-IFN, TNF-α and IL-10 (the last two indices indicated a restoration of the balance of pro- and anti-inflammatory cytokines). Activation of the humoral pathway of the immune response was observed after month after the introduction of the first dose of CervarixТМ – an increase in comparison with control the median for IL-10 was observed 2.5 – fold against with 2.2 – fold before vaccination.

Downloads

Download data is not yet available.

References

1. Kiselyov F. L. Virusyi papillom cheloveka kak etiologicheskiy faktor raka sheyki matki: znachenie dlya praktiki zdravoohraneniya // Vopr. virusologii. – 1997. – T. 42, # 6. – S. 248–251.
2. Rebrova O. Yu. Statisticheskiy analiz meditsinskih dannyih: primenenie paketa prikladnyih programm STATISTISA. – M.: Media Sfera, 2002. – 312 s.
3. Skoups R. Metodyi ochistki belkov. – M.: Mir, 1985. – S. 466–467.
4. Trushina O. I. Rol papillomavirusnoy infektsii v geneze RShM // Ros. onkol. zhurn. – 2005. – # 1. – S. 45–52.
5. Franco E. L., Villa L. L., Richardson H. et al. Epidemiology of Cervical Human Papillomavirus Infection // In: New developments in cervical cancer screening and prevention. – Oxford: Blackwell Science, 1997. – Р. 14–¬22.
6. Insinga R. P., Dasbach E. J., Elbasha E. H. et al. Cost-effectiveness of quadrivalent human papillomavirus (HPV) vaccination in Mexico: a transmission dynamic model-based evaluation // Vaccine. – 2007. – Vol. 26, N 1. – P. 128–139.
7. Keam S. J., Harper D. M. Human papillomavirus types 16 and 18 vaccine (recombinant, AS04 adjuvanted, adsorbed) [Cervarix] // Drugs. – 2008. – Vol. 68, N 3. – P. 359–372.

Abstract views: 94
PDF Downloads: 60
Published
2018-06-27
How to Cite
Dola, O. L., Lakatosh, V. P., Antonuk, M. I., & Lakatosh, P. V. (2018). Indicators of local immunity in women with percistant form of latent papillomavirus cervical infection after immunization with vaccine against HPV. Likarsʹka Sprava, (3-4), 41-46. https://doi.org/10.31640/3-4.2018(6)
Section
Immunopathology of human