Immune microenvironment in breast cancer

  • L. A. Sivak National Cancer Institute
  • A. N. Grabovyj National Cancer Institute
  • N. O. Verovkina National Cancer Institute
  • S. A. Lyalkin National Cancer Institute
  • N. M. Majdanevych National Cancer Institute
  • A. V. Askolskyy National Cancer Institute
  • M. Yu. Klimanov National Cancer Institute
Keywords: breast cancer, tumor microenvirolement, chemotherapy, anti-HER2 therapy


Traditionally, breast cancer has not been considered as a typical immunogenic tumor type. Nevertheless, it is well known that breast cancer is a heterogeneous mixture of different molecular subtypes and infiltration of tumor tissue by immunocompetent cells is associated with response to chemotherapy and survival in a certain molecular subtypes of breast cancer. Analysis of works of various research groups suggests that, immune markers, such as the presence of CD8 + lymphocytes, T regulatory cells in the tumor, as well as the ratio of CD8/CD4T should be used to stratify risk groups with prognostically unfavorable types of breast cancer as well as use as a factor in predicting the effectiveness of anti-HER2 therapy and chemotherapy for triple negative and HER2-overexpressing breast cancer subtypes.


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How to Cite
Sivak, L. A., Grabovyj, A. N., Verovkina, N. O., Lyalkin, S. A., Majdanevych, N. M., Askolskyy, A. V., & Klimanov, M. Y. (2017). Immune microenvironment in breast cancer. Likars’ka Sprava, (1-2), 83-88.
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