Immunological predictors of intrauterine infection of the fetus and newborn in pregnancies complicated by bacterial and viral infection

  • N. A. Shcherbina Kharkiv National Medical University
  • L. A. Vygovskaya Kharkiv National Medical University
Keywords: intrauterine infection of the fetus, cellular immunity, cytokines

Abstract

The study involved the assessment of the state of immune system in pregnant women with bacterial and viral urogenital infection to determine the criteria for implementation of intrauterine infection (IUI) of the fetus and newborn. It implied a comparative study of the state of some parameters of immune system in 150 pregnant women with urogenital infection of mixed bacterial and viral genesis, who were in a risk group for the development of fetal IUI at the 2nd–3rd trimesters of gestation. The main group comprised 68 (45.3 %) women whose children, according to clinical and laboratory examination, had IUI. The comparison group included 82 (54.7 %) carriers of perinatally significant bacterial and viral infection who gave birth to healthy children; the control group included 50 healthy women with normal pregnancy. The study determined immunological features of pregnancy, complicated with fetal IUI. Evaluation of cytokine link in regulation of immunity in the group of pregnant women with implementation of IUI made it possible to establish a significant increase in IL-1β, IL-6, IL-10, TNF-α levels in the 2nd-3rd trimesters, with a simultaneous decrease in IL-10, more expressed in the subgroup of pregnant women, who gave birth to children diagnosed with IUI, in comparison with pregnant women, whose newborns did not have clinical manifestations of the disease with a confirmed IUI. Implementation of IUI in pregnancy complicated by urogenital infection of bacterial and viral etiology at late terms of gestation is associated with an imbalance between pro- and anti-inflammatory cytokines, with the dominance of proinflammatory cytokines, the indices of which can be used as predictors for implementation of fetal IUI.

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Author Biography

N. A. Shcherbina, Kharkiv National Medical University

Department of Obstetrics and Gynecology № 1 (Head – prof. N. А. Shcherbina)

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Abstract views: 93
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Published
2018-06-27
How to Cite
Shcherbina, N. A., & Vygovskaya, L. A. (2018). Immunological predictors of intrauterine infection of the fetus and newborn in pregnancies complicated by bacterial and viral infection. Likarsʹka Sprava, (3-4), 35-41. https://doi.org/10.31640/JVD.3-4.2018(5)
Section
Immunopathology of human