Vascular continuum in chronic kidney disease: focus on osteopontin

  • V. A. Vizir Zaporizhzhia State Medical University
  • A. S. Sadomov Zaporizhzhia State Medical University
  • O. G. Ovska Zaporizhzhia State Medical University
Keywords: chronic kidney disease, intima-medial segment thickness, vascular calcification, osteopontin

Abstract

            Chronic kidney disease (CKD) is widespread among the general population and affects the quality of life. It is characterized by high level of mortality due to lesion of cardiovascular system. We studied the role of the plasma fraction of osteopontin (OP) in the development of vascular calcification (VC) and progression of vascular remodeling, as well as the relationship between OP and bone mineral lesions in patients with pre-dialysis stages of CKD. Patients with CKD III, IV and V stages (n = 52) were subjected to a general clinical examination, an office blood pressure (BP) measurement, assessment of serum levels of total calcium and phosphorus, calculation of phosphorus-calcium product, immunoassay of intact parathyroid hormone (IPTG) and OP. The intima-medial segment thickness (TIMS), indices of resistivity (RI) and pulsation (PI) of the common carotid artery, and the prevalence of calcification of the abdominal aorta (AA) were estimated using lateral radiography (in millimeters). It was found that the bone-mineral metabolism index was deteriorated with the progression of CKD as the statistically significant increase of serum level of phosphate, phosphorus-calcium product and IPTG, and a significant increase in the plasma OP concentration. Impairment of renal function was accompanied by progression vascular remodeling processes by way of an increase in TIMS, RI and a decrease in PI. A direct positive relationship was found between the level of OP and the calcification length of the AA (r = +0.35 %; P < 0.05), phosphatemia (r = +0.32; P < 0.05), ІPTG (r = +0, 49; P < 0.05) and TIMS (r = +0.37; P < 0.05). The performed statistical analysis indicated a possible key role of OP in the development of vascular calcification and structural alteration of the vessels in pre-dialysis stages of CKD.

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Published
2017-03-30
How to Cite
Vizir, V. A., Sadomov, A. S., & Ovska, O. G. (2017). Vascular continuum in chronic kidney disease: focus on osteopontin. Likars’ka Sprava, (1-2), 74-83. Retrieved from https://liksprava.com/index.php/journal/article/view/18
Section
Original intestigations