Vascular continuum in chronic kidney disease: focus on osteopontin
Abstract
Chronic kidney disease (CKD) is widespread among the general population and affects the quality of life. It is characterized by high level of mortality due to lesion of cardiovascular system. We studied the role of the plasma fraction of osteopontin (OP) in the development of vascular calcification (VC) and progression of vascular remodeling, as well as the relationship between OP and bone mineral lesions in patients with pre-dialysis stages of CKD. Patients with CKD III, IV and V stages (n = 52) were subjected to a general clinical examination, an office blood pressure (BP) measurement, assessment of serum levels of total calcium and phosphorus, calculation of phosphorus-calcium product, immunoassay of intact parathyroid hormone (IPTG) and OP. The intima-medial segment thickness (TIMS), indices of resistivity (RI) and pulsation (PI) of the common carotid artery, and the prevalence of calcification of the abdominal aorta (AA) were estimated using lateral radiography (in millimeters). It was found that the bone-mineral metabolism index was deteriorated with the progression of CKD as the statistically significant increase of serum level of phosphate, phosphorus-calcium product and IPTG, and a significant increase in the plasma OP concentration. Impairment of renal function was accompanied by progression vascular remodeling processes by way of an increase in TIMS, RI and a decrease in PI. A direct positive relationship was found between the level of OP and the calcification length of the AA (r = +0.35 %; P < 0.05), phosphatemia (r = +0.32; P < 0.05), ІPTG (r = +0, 49; P < 0.05) and TIMS (r = +0.37; P < 0.05). The performed statistical analysis indicated a possible key role of OP in the development of vascular calcification and structural alteration of the vessels in pre-dialysis stages of CKD.
Downloads
References
Візір В. А., Березін О. Є. Остеопонтин як новий біологічний маркер кардіоваскулярного ремоделювання // Кровообіг та гемостаз. – 2010. – Вип. 27–28, № 1–2. – С. 42–47.
Волков М. М., Смирнов А. В. Рентгенологическая оценка кальцификации брюшной аорты у больных с хронической болезнью почек, получающих гемодиализ: частота выявления и ассоциированные факторы // Нефрология. – 2010. – № 14. – С. 37–45.
Гусева С. А., Гончаров Я. П. Анемии при хронической почечной недостаточности. – К.: Логос, 2004. – 408 с.
Земченков А. Ю., Герасимчук Р. П. Активаторы рецепторов витамина D и сосудистая кальцификация // Нефрология и диализ. – 2009. – Вып. 11, № 4. – С. 276–291.
Колесник М. О., Сайдакова Н. О., Козлюк Н. І., Ніколаєнко С. С. Медико-профілактична допомога хворим нефрологічного профілю 2009–2012, що робити далi? [Електронний ресурс] // Укр. журн. нефрології і діалізу. – 2013. – Вип. 39, № 3. – Режим доступу: http://ukrjnd.com.ua/pages/view/170
Котанко П. Причины и последствия гиперактивности симпатической нервной системы при хронических заболеваниях почек [Электронный ресурс] // Обзоры клинич. кардиологии. – 2008. – № 16. – Режим доступу: http: //www.cardiosite.ru/info.aspx?rubricid=85.
Національний реєстр хворих на хронічну хворобу нирок: 2012 рік / уклад. Н. І. Козлюк, С. С. Ніколаєнко, М. В. Кулизький; ДУ «Інститут нефрології НАМН України»; гол. ред. М. О. Колесник. – К., 2013. – 89 с.
Adragao T., Pires A., Birne R. et al. A plain X-ray vascular calcification score is associated with arterial stiffness and mortality in dialysis patients // Nephrol. Dial. Transplant. – 2009. – Vol. 24. – P. 997–1002.
Choi S. T., Kim J. H., Kang E. J., Lee S. W. Osteopontin might be involved in bone remodelling rather than in inflammation in ankylosing spondylitis // Rheumatology. – 2008. – Vol. 47, N 12. – P. 1775–1779.
Fang Wei, Yang Xiao, Bargman Joanne M. et al. Аssociation between pulse pressure and mortality in patients undergoing peritoneal dialysis // Perit Dial Int. – 2009. – Vol. 29, N 2. – P. 163–170.
Floege J., Kim J., Ireland E. et al. iPTH, calcium and phosphate, and the risk of mortality in a European haemodialysis population // Nephrol. Dial. Transplant. – 2011. – Vol. 26. – P. 1948–1955.
Grau J. B., Poggio P., Sainger R. et al. Analysis of Osteopontin Levels for the Identification of Asymptomatic Patients with Calcific Aortic Valve Disease // Ann. Thoracic Surg. – 2012. – Vol. 93, N 1. – P. 79–86.
Lee J. S., Basalyga D. M., Simionescu A. et al. Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses // Am. J. Pathol. – 2006. – Vol. 168. – P. 490–498.
London G. M. Bone-vascular cross-talk // J. Nephrol. – 2012. – Vol. 25. N 05. – P. 619–625.
Lorenzen J. M., Hafer C., Faulhaber-Walter R. et al. Osteopontin predicts survival in critically ill patients with acute kidney injury // Nephrol. Dial. Transplant. – 2010. – Vol. 26, N 2. – P. 531–537.
Lorenzen J., Krämer R., Kliem V. et al. Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease // Eur. J. Clin. Invest. – 2010. – Vol. 40, N 4. – P. 294–300.
Lu Kuo-Cheng, Wu Chia-Chao, Yen Сhen-Fen et al Vascular Calcification and Renal Bone Disorders [Електронний ресурс] // The Scientific World J. – 2014. – Vol. 2014. – Режим доступу: http://dx.doi.org/10.1155/2014/637065
Abstract views: 83 PDF Downloads: 29
This work is licensed under a Creative Commons Attribution 4.0 International License.
ISSN 
ISSN 
