Leptin and insulin resistance in patients with osteoarthritis combined with obesity and the dynamics of their levels on the background of treatment with symptomatic fast-acting drugs (sodium naproxen)

  • O. V. Kuryata SE "Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine"
  • G. V. Cherkasova SE "Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine"
Keywords: osteoarthritis, obesity, adipokines, naproxen sodium

Abstract

The aim – to assess the level of leptin and insulin resistance in patients with osteoarthritis depending on obesity and the effect of treatment with naproxen sodium. Materials and methods. The study was conducted at the Department of Rheumatology of the MI "Mechnikov Dnipropetrovsk Regional Clinic". The study included 30 women with OA aged 40 to 75 years with OA I-III X-ray stage according to Kellgren and Lawerence with synovitis phenomena; the pain level for the visual analogue scale (VAS) > 3 points; obesity I-III degree (body mass index – BMI 30–49.9 kg/m2) after receiving their informed consent. Results. Obesity among patients with OA was associated with higher pain level in knees using VAS. The degree of motor limitations in the WOMAC index increased proportionally with the increase in BMI. The level of systemic inflammation in OA patients with obesity was significantly higher. Treatment with naproxen significantly reduced the level of leptin, regardless of obesity. Conclusions. The use of naproxen sodium (naproff) in patients with OA with synovitis leads to a pronounced analgesic and anti-inflammatory effects. Leptin plays an important role in the formation of insulin resistance and maintenance of low-level inflammation in OA in obese individuals.

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Published
2017-12-30
How to Cite
Kuryata, O. V., & Cherkasova, G. V. (2017). Leptin and insulin resistance in patients with osteoarthritis combined with obesity and the dynamics of their levels on the background of treatment with symptomatic fast-acting drugs (sodium naproxen). Likars’ka Sprava, (8), 120-129. Retrieved from https://liksprava.com/index.php/journal/article/view/141
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