Leptin and insulin resistance in patients with osteoarthritis combined with obesity and the dynamics of their levels on the background of treatment with symptomatic fast-acting drugs (sodium naproxen)

O. V. Kuryata; G. V. Cherkasova

O. V. Kuryata SE "Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine"
G. V. Cherkasova SE "Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine"

Keywords: osteoarthritis, obesity, adipokines, naproxen sodium

Abstract

The aim – to assess the level of leptin and insulin resistance in patients with osteoarthritis depending on obesity and the effect of treatment with naproxen sodium. Materials and methods. The study was conducted at the Department of Rheumatology of the MI "Mechnikov Dnipropetrovsk Regional Clinic". The study included 30 women with OA aged 40 to 75 years with OA I-III X-ray stage according to Kellgren and Lawerence with synovitis phenomena; the pain level for the visual analogue scale (VAS) > 3 points; obesity I-III degree (body mass index – BMI 30–49.9 kg/m²) after receiving their informed consent. Results. Obesity among patients with OA was associated with higher pain level in knees using VAS. The degree of motor limitations in the WOMAC index increased proportionally with the increase in BMI. The level of systemic inflammation in OA patients with obesity was significantly higher. Treatment with naproxen significantly reduced the level of leptin, regardless of obesity. Conclusions. The use of naproxen sodium (naproff) in patients with OA with synovitis leads to a pronounced analgesic and anti-inflammatory effects. Leptin plays an important role in the formation of insulin resistance and maintenance of low-level inflammation in OA in obese individuals.

Downloads

Download data is not yet available.

References

Akarachkova E. S. Rol vegetativnoj nervnoj sistemy v patogeneze golovnoj boli napryazheniya. Avtoref. dis. … d-ra med. nauk. – M., 2012. – 48 s.
Akarachkova E. S. Hronicheskij stress i narushenie adaptacii u medicinskih rabotnikov // Trudnyj pacient. – 2006. – № 8. – S. 6–8.
Belovol A. N., Knyazkova I. I., Nesen A. A., Chirva O. V. Arterialnaya gipertenziya u molodyh muzhchin:fokus na gipomagniemiyu // Medicinskie aspekty zdorovya muzhchiny. – 2015. – № 2. – S. 55–62.
Gromova O. A. Magnij i piridoksin: osnovy znanij. – M.: ProtoTip, 2006. – 234 s.
Dyuzhikova N. A. Citogeneticheskie i molekulyarno-kletochnye mehanizmy poststressornyh sostoyanij. Avtoref. dis. … d-ra med. nauk. – SPb, 2016. – 42 s.
Kalacheva A. G. Element-specificheskie indikatory nejrotropnyh funkcij magniya. Avtoref. dis. … kand. med. nauk. – M., 2011. – 24 s.
Nemkova S. A., Maslova O. I., Zavadenko N. N. i dr. Kompleksnaya diagnostika i korrekciya narushenij sna u detej // Pediatr. farmakologiya. – 2015. – Vyp. 12, № 2. – P. 180–189.
Torshin I. Yu., Gromova O. A. Molekulyarnye funkcii magnij-zavisimyh belkov miokarda ukazyvayut na perspektivy kardiologicheskogo primeneniya preparatov na osnove orotata magniya // Farmateka. – 2016. – № 9. – S. 54–58.
Tutelyan V. A., Spirichev V. B., Suhanov B. P., Kudasheva V. A. Mikronrienty v pitanii zdorovogo i bolnogo cheloveka, spravochnoe rukovodstvo po vitaminam i mineralnym veshestvam. – M.: Kolos, 2002. – 240 s.