Effects of probiotics on intestinal microflora of patients with hiv

  • K. N. Gorobchenko Sumy State University
  • A. G. Dyachenko Sumy State University
  • O. M. Savinova Mechnikov Institute of Microbiology and Immunology of Ukrainian Medical Sciences Academy
  • T. V. Ivakhnjuk Sumy State University
Keywords: HIV-infection, intestinal microflora, probiotics

Abstract

HIV-1 infection results in structural damage to the intestinal mucosa and changes of gut microflora following dysfunction of the gastrointestinal system, including compromised barrier function. Known properties of probiotics suggest that they may be useful tools in restoring normal intestinal flora. Our study goal was to determine whether the use of a probiotics can recover normal gut flora in chronically HIV-infected adults. Standard bacteriological methods were used to exam the gut microbial content of the HIV-infected patients. Changes of intestinal microbiota were found in all of the patients. In the most cases the decrease of obligatory microorganisms, especially Bifidobacterium spp. (in 90 % of patients) was found. Overgrowth of major opportunistic pathogens (S. aureus and Candida spp.) was registered in only a minority of patients. The probiotic interventions resulted in significantly elevated levels of beneficial bacteria load (such as Bifidobacterium spp., Lactobacillus spp.) and a decrease in patogenic bacteria load (such as Clostridium, Candida spp.). Probiotic preparations can successfully augment the levels of beneficial species in the gut during chronic HIV-1 infection. These findings may help inform future studies aimed at testing pre- and probiotic approaches to improve gut function and mucosal immunity in chronic HIV-1 infection.

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Published
2017-12-30
How to Cite
Gorobchenko, K. N., Dyachenko, A. G., Savinova, O. M., & Ivakhnjuk, T. V. (2017). Effects of probiotics on intestinal microflora of patients with hiv. Likars’ka Sprava, (8), 110-114. https://doi.org/10.31640/LS-2017-8-15
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