Interconnection of genetic and social risk factors depending on the time of onset of ischemic stroke
Abstract
The presented research is devoted to the definition of the interconnection of genetic and social risk factors depending on the time of the onset of acute ischemic stroke. The analysis of 150 patients with acute ischemic stroke confirms that patients with different incidence of stroke symptoms have a characteristic difference in the spectrum of social predictors. Sufficiently high concentration of pathogenic mutation of the TTH gene of MTHFR C7661T was observed only in the group of patients with the daytime period of stroke symptoms, it can be concluded that the social risk pattern of the first group of patients served as a characteristic trigger for activating the pathological effect of the mutated locus 7661 of the MTHFR gene, which is has led to the occurrence of ischemic stroke in 20.5 % of patients in this subgroup.
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