Interconnection of genetic and social risk factors depending on the time of onset of ischemic stroke

  • I. S. Zozulya Shupyk National Medical Academy of Postgraduate Education, Kyiv
  • A. I. Zozulya Shupik National Medical Academy of Postgraduate Education
  • A. O. Volosovets Shupik National Medical Academy of Postgraduate Education
Keywords: risk factors, stroke, genetic research, social predictors.

Abstract

The presented research is devoted to the definition of the interconnection of genetic and social risk factors depending on the time of the onset of acute ischemic stroke. The analysis of 150 patients with acute ischemic stroke confirms that patients with different incidence of stroke symptoms have a characteristic difference in the spectrum of social predictors. Sufficiently high concentration of pathogenic mutation of the TTH gene of MTHFR C7661T was observed only in the group of patients with the daytime period of stroke symptoms, it can be concluded that the social risk pattern of the first group of patients served as a characteristic trigger for activating the pathological effect of the mutated locus 7661 of the MTHFR gene, which is has led to the occurrence of ischemic stroke in 20.5 % of patients in this subgroup.

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References

Zozulya I. S., Volosovec A. O. Suchasni faktori riziku gostrogo ishemichnogo insultu: Metod. rekomendaciyi. – K., 2016. – 28 s.
Mishenko T. S. Epidemiologiya cerebrovaskulyarnyh zabolevanij i organizaciya pomoshi bolnym s mozgovym insultom v Ukraine // Ukr. visn. psihonevrologiyi. – 2017. – T. 25, Vip. 90, № 1. – S. 22–24.
Smulska N. O., Kir’yachenko S. P., Gorovenko N. G., Zozulya I. S. Asociaciya polimorfnih variantiv geniv MTHFR (C677T), MTHFR (A1298C), MTRR (A66G), FV (G1691A), FII (G20210A), ACE (I/D) ta yih kombinacij u riziku rozvitku ishemichnogo insultu v dityachomu vici // Ukr. med. chasopis. – 2014. – Vip. 101, № 3 (V/VI). – S. 131–134.
Arsene D., Găină G., Bălescu C., Ardeleanu C. C677T and A1298C methylenetetrahydropholate reductase (MTHFR) polymorphisms as factors involved in ischemic stroke // Rom. J. Morphol. Embryol. – 2011. – Vol. 52, N 4. – P. 1203–1207.
Han L., Wu Q., Wang C. et al. Homocysteine, ischemic stroke, and coronary heart disease in hypertensive patients: a population-based, prospective cohort study // Stroke. – 2015. – Vol. 46. – P. 1777–1786.
Husemoen L. L., Skaaby T., Jorgensen T. et al. Mthfr c677t genotype and cardiovascular risk in a general population without mandatory folic acid fortifica // Eur. J. Nutr. – 2014. – Vol. 53. – P. 1549–1559.
Go A. S., Mozaffarian D., Roger V. L. et al. American Heart Association. Heart disease and stroke statistics –2014 update: a report from the American Heart Association // Am. Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. – 2014. – Vol. 129, N 3. – P. 292.
Jin P., Hou S., Ding B. et al. Association between MTHFR gene polymorphisms, smoking, and the incidence of vascular dementia // Asia Pac. J. Public. Health. – 2013. – Vol. 25 (Suppl 4). – P. 57S–63S.
Soltanpour M. S., Soheili Z., Shakerizadeh A. et al. Methylenetetrahydrofolate reductase C677T mutation and risk of retinal vein thrombosis // J. Res. Med. Sci. – 2013. – Vol. 18, N 6. – P. 487–491.
Zhang M. J., Hu Z. C., Yin Y.W. et al. A Meta-Analysis of the Relationship between MTHFR Gene A1298C Polymorphism and the Risk of Adult Stroke // Cerebrovasc. Dis. – 2014. – Vol. 38, N 6. – P. 425–432.

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Published
2017-12-30
How to Cite
Zozulya, I. S., Zozulya, A. I., & Volosovets, A. O. (2017). Interconnection of genetic and social risk factors depending on the time of onset of ischemic stroke. Likars’ka Sprava, (8), 51-55. https://doi.org/10.31640/LS-2017-8-06
Section
Original investigations