High-dose i/v immunoglobulin therapy efficiency in children with autism spectrum disorders associated with genetic deficiency of folate cycle enzymes

  • D. V. Maltsev Bohomolets National Medical University
Keywords: folate cycle, i/v immunoglobulin, autism spectrum disorder

Abstract

To evaluate high-dose immunoglobulin therapy efficacy and safety in children with autism spectrum disorders and genetic deficiency of folate cycle. The studied group consisted of 78 children aged 2 to 10 years who have been on i/v immunoglobulin at a dose of 2 g/kg 1 month for 6 months. The control group included children of similar age and gender distribution, which received only non-drug rehabilitation support. There were detected by PCR such polimorphisms as MTHFR 677 C > T, MTHFR 1298 A > C, MTRR A/G and MTR A/G in various combinations. The dynamics of psychiatric symptoms were assessed using the Aberrant Behavior Checklist scale. It has reached the complete elimination of the phenotype of autism spectrum disorders in 21 patients and a marked improvement in 33 children of study group (P < 0,05; Z < Z0,05). In parallel, we evaluated positive dynamic of other clinical manifestations of folate cycle deficiency phenotype: PANDAS (19 of 21), epilepsy (29 of 36) and gastrointestinal (in 49 out of 68 children) syndromes (P < 0,05; Z < Z0,05). There was no positive dynamics of the pyramidal tract lesion symptoms (P > 0,05; Z > Z0,05). Decrease of the total viral load and increasing the number of natural killer cells in the blood were achieved (P < 0,05; Z < Z0,05). Almost complete elimination leukoencephalopathy MR-symptoms was observed in 29 patients, and positive dynamics – in 24 cases in the study group (P < 0,05; Z < Z0,05). I/v immunoglobulin has a complex positive impact on the manifestation of a genetic deficiency of folate cycle, including autism spectrum disorders, extrapyramidal disturbances, bowel syndrome, epileptiform brain activity, immune deficiency, and leukoencephalopathy.

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Published
2017-12-30
How to Cite
Maltsev, D. V. (2017). High-dose i/v immunoglobulin therapy efficiency in children with autism spectrum disorders associated with genetic deficiency of folate cycle enzymes. Likars’ka Sprava, (8), 8-24. https://doi.org/10.31640/LS-2017-8-02
Section
Immunopathology of human