Serum level of fibronectin in patients with arterial hypertension
Abstract
To investigate serum levels of fibronectin in hypertensive patients, as a marker of endothelial dysfunction, the relationship of this factor of endothelium-dependent dilatation and other risk factors of cardiovascular disease. Were examined 68 hypertensive patient and 18 control subjects. Serum levels of fibronectin were determined by immunoenzyme assay. Endothelium-dependent dilatation was measured by standard method of Celermajer. Were found an increased serum level of fibronectin in hypertensive patients compared to control (336,48 pmol/ml ± 71,73 pmol/ml and 222,66 pmol/ml ± 36,93 pmol/ml respectively; Р < 0,05). Also, the level of fibronectin correlated with endothelium-dependent dilatation, serum levels of insulin, HOMA, total cholesterol, HDL, LDL, triglycerides, HbA1c, blood glucose, body mass index (Р < 0,05). There is an elevation of serum level of fibronectin and an alteration of endothelium-dependent dilatation in arterial hypertension. Hyperglycemia, dyslipidemia, insulin resistance, and obesity appears to be significant factor to contributing elevation of fibronectin. The revealed change could reflect an endothelial dysfunction in this pathological state.
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